Versatile Mechanical Bioreactor
Adipokine Effects on Joint Matrix
We explored how adipokines influence extracellular matrix synthesis and degradation in cartilage and meniscus explants. Exposure induced catabolic activity and reduced accumulation of newly synthesized proteoglycans. These results link metabolic signaling to joint inflammation and suggest targets for mitigating obesity-related joint degeneration.
Confined Mechanics Drive Matrix Formation
We examined how mechanical confinement during culture affects cartilage matrix deposition by chondrocytes. Restricted deformation enhanced collagen organization and increased tissue stiffness, demonstrating that geometric constraints regulate matrix assembly. This finding informs bioreactor design for engineering cartilage with native-like mechanical properties.
Multi-Axis Bioreactor for Meniscus Culture
We designed and validated a mechanical loading bioreactor capable of applying complex multi-axis deformation to meniscus explants. The system enables precise control of dynamic strain environments during long-term culture. This platform supports mechanobiology studies and development of tissue-engineered meniscus replacements.